During Hurricane Katrina in 2005, PAWS volunteers drove from Chicago to Louisiana to rescue 200 pets caught in the floods. PAWS works with shelters across the U.S., particularly in times of crisis and natural disaster. It was the first cage-free shelter in the Midwest. The new adoption center cost $9 million and is 13,000 square feet.

On September 7, 2007, PAWS opened its Lincoln Park adoption center located at 1997 N. In 2000, PAWS opened the Lurie Spay and Neuter Clinic. The clinic offers free and low cost services in the Chicago area, performing over 17,000 spray and neuter surgeries each year. The event was held on Michigan Ave in Chicago, where the organization partnered with local businesses and boutiques who agreed to showcase animals in their storefronts. The event facilitated animal adoptions, and was intended to raise awareness around the issue of pet overpopulation and the euthanasia of homeless animals. In 1998, Fasseas launched PAWS Chicago with an adoption event titled 'Angels with Tails' aiming to save the lives of stray or homeless animals. The duo aspired to create an organization that focused on discovering solutions to end the euthanasia of homeless pets. The organization was co-founded in 1997 by Paula Fasseas and her daughter Alexis Fasseas. PAWS Chicago ( Pets Are Worth Saving) is a non-profit animal shelter organization based in Chicago, Illinois.

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